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Jena Bioscience抗病毒核苷/核苷酸類似物--助力新型冠狀病毒藥物研發(fā)

持續(xù)近兩個(gè)多月的新型冠狀病毒感染的肺炎疫情牽動(dòng)著每一個(gè)人的心，為了打贏這場(chǎng)疫情防控狙擊戰(zhàn)，搞清致病機(jī)理，研發(fā)抗病毒藥物和疫苗刻不容緩。Jena bioscience品牌有豐富的抗病毒核苷酸/核苷酸類似物，助力抗病毒藥物研發(fā)。

抗病毒核苷及核苷酸類似物主要有:

抗病毒核苷/核苷酸類似物可以通過(guò)抑制病毒復(fù)制的幾個(gè)關(guān)鍵過(guò)程來(lái)抑制病毒繁殖，它們通過(guò)與天然的dNTP/NTP競(jìng)爭(zhēng)結(jié)合到新的病毒核酸中，從而導(dǎo)致鏈終止或者誘變。在細(xì)胞培養(yǎng)實(shí)驗(yàn)中，可以用抗病毒核苷酸的非磷酸化核苷變體，這種核苷酸在細(xì)胞內(nèi)被多種病毒和/或宿主激酶激活，從而發(fā)揮(tri)磷酸化形式的抗病毒作用。

熱銷抗病毒核苷/核苷酸類似物：

品牌	貨號(hào)	品名	規(guī)格
Jena Bioscience	NU-1605S	3TCMP	10 μl (10 mM)
Jena Bioscience	NU-1605L	3TCMP	5 x 10 μl (10 mM)
Jena Bioscience	NU-1606S	3TCTP	5 μl (10 mM)
Jena Bioscience	NU-1606L	3TCTP	5 x 5 μl (10 mM)
Jena Bioscience	NU-1603S	d4TMP	20 μl (10 mM)
Jena Bioscience	NU-1603L	d4TMP	5 x 20 μl (10 mM)
Jena Bioscience	NU-1601S	AzTMP	20 μl (10 mM)
Jena Bioscience	NU-1601L	AzTMP	5 x 20 μl (10 mM)
Jena Bioscience	NU-989S	AzTTP	10 μl (100 mM)
Jena Bioscience	NU-989L	AzTTP	5 x 10 μl (100 mM)
Jena Bioscience	NU-875	ara-Adenosine-5'-monophosphate (ara-AMP)	2 mg
Jena Bioscience	NU-1111S	ara-Adenosine-5'-triphosphate (ara-ATP)	50 μl (10 mM)
Jena Bioscience	NU-1111L	ara-Adenosine-5'-triphosphate (ara-ATP)	5 x 50 μl (10 mM)
Jena Bioscience	NU-876	Acyclovir-5'-monophosphate	2 mg
Jena Bioscience	NU-877	Acyclovir-5'-triphosphate	2 mg
Jena Bioscience	NU-021-2	Ribavirin-5'-monophosphate	2 mg
Jena Bioscience	NU-1105S	Ribavirin-triphosphate	20 μl (10 mM)
Jena Bioscience	NU-1105L	Ribavirin-triphosphate	5 x 20 μl (10 mM)
Jena Bioscience	N-DN-8234-100	β-L-2'-Deoxythymidine	100 mg
Jena Bioscience	NU-896S	6-Aza-UTP	10 μl (100 mM)
Jena Bioscience	NU-896L	6-Aza-UTP	5 x 10 μl (100 mM)
Jena Bioscience	NU-974	Tenofovir	100 mg
Jena Bioscience	NU-975	Tenofovir-diphosphate	1 mg
Jena Bioscience	NU-989S	AzTTP	10 μl (100 mM)
Jena Bioscience	NU-989L	AzTTP	5 x 10 μl (100 mM)
Jena Bioscience	NU-275S	Ganciclovir-triphosphate	10 μl
Jena Bioscience	NU-275L	Ganciclovir-triphosphate	5 x 10 μl

西美杰是Jena bioscience中國(guó)總代理，為用戶提供完善的技術(shù)與售后服務(wù)。如對(duì)產(chǎn)品感興趣歡迎撥打西美杰客服熱線400-050-4006了解詳細(xì)信息。西美杰會(huì)更好的協(xié)助科研工作者的實(shí)驗(yàn)工作，支持全國(guó)戰(zhàn)“疫”，早日戰(zhàn)勝病毒。武漢加油！中國(guó)加油！

參考文獻(xiàn)：

1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18.
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740.
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154.
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34.
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375.
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press.
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.